Differential regulation of polarized synaptic vesicle trafficking and synapse stability in neural circuit rewiring in Caenorhabditis elegans.
Neural circuits are dynamic, with activity-dependent changes in synapse density and connectivity peaking during different phases of animal development.In C.elegans, young larvae form mature motor circuits through a dramatic switch in GABAergic neuron connectivity, by concomitant elimination of existing synapses and formation of new synapses that ar